The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might result in a rise in methadone plasma concentrations, which could induce likely fatal respiratory melancholy. In addition, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also result in an increase i